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AA amyloidosis is a form of amyloidosis, a disease characterized by the abnormal deposition of fibers of insoluble protein in the extracellular space of various tissues and organs. In AA amyloidosis, the deposited protein is serum amyloid A protein (SAA), an acute-phase protein which is normally soluble and whose plasma concentration is highest during inflammation. == Causes == AA amyloidosis is a complication of a number of inflammatory diseases and infections,〔Chapter 5 in: 8th edition.〕 although only a small portion of patients with these conditions will go on to develop AA amyloidosis. A natural history study of AA amyloidosis patients published in the New England Journal of Medicine reported a number of conditions associated with AA amyloidosis.〔 The most common presentation of AA amyloidosis is renal in nature, including proteinuria, nephrotic syndrome and progressive development of renal insufficiency leading to End Stage Renal Disease (ESRD) and need for renal replacement therapy (e.g. dialysis or renal transplantation). * Autoimmune diseases * * Rheumatoid arthritis * * Ankylosing spondylitis * * Crohn's disease and ulcerative colitis * Chronic infections * * Tuberculosis * * Bronchiectasis * * Chronic osteomyelitis * Autoinflammatory diseases * * Familial Mediterranean fever (FMF) * * Muckle-Wells syndrome (MWS) * Cancer * * Hodgkin's lymphoma * * Renal cell carcinoma * Chronic foreign body reaction * * Silicone-induced granulomatous reaction 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「AA amyloidosis」の詳細全文を読む スポンサード リンク
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